Unlock the hidden potential of formulations with DropBrigt® HEPES (INCI: Hydroxyethylpiperazine Ethane Sulfonic Acid, CAS 7365-45-9)—a bio-compatible buffer that transcends pH control to deliver exfoliation, brightening, and UV-protective synergy. Backed by cutting-edge 3D skin models, here’s why this versatile active belongs in your next brightening or anti-aging formula.
🌟 Triple-Action Benefits
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Gentle Exfoliation
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Weak acid (pH 4.5–6.5) with macromolecular AHA-like properties.
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Softens keratinocytes, smooths texture, and boosts cell turnover without irritation at recommended doses (0.5–5%).
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Clinical Brightening Power
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Proven Synergy: In 3D melanin skin models, formulations with HEPES + tranexamic acid + AA2G + niacinamide (Composition A):
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↑ L* value (brightness) by 15% vs. controls (P<0.01)
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↓ Melanin content by 30% (P<0.01)
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Outperformed fewer-actives combos (B/C) in reducing UV-induced pigmentation.
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UV Absorption & Penetration Boost
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Absorbs UVA/visible light, offering secondary photoprotection.
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Enhances delivery of co-actives (e.g., vitamin C, niacinamide).
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🔬 Science Spotlight: Brightening Synergy
| Test Parameter | Composition A | Composition B | Composition C |
|---|---|---|---|
| Tranexamic Acid | 3% | – | – |
| AA2G | 1% | 1% | – |
| Niacinamide | 2% | 5% | 6% |
| HEPES | 0.5% | 0.5% | 0.5% |
| Result vs. UV-Damaged Skin | ↑ L* value 15% ↓ Melanin 30% |
Moderate improvement | Minimal impact |
Key Insight: HEPES amplifies brightening efficacy in multi-active systems—0.5% HEPES doubled melanin reduction vs. niacinamide-only formulas.
⚙️ Formulator-Friendly Profile
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Solubility: Water-soluble (1M solution: clear, colorless).
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Stability: Heat/light-stable; pH 4–8 compatible.
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Addition: Flexible—cold or hot process (≤80°C).
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Safety:
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Mild irritation (IS=4.77 at 2% in chicken embryo test).
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Optimal use: 0.5–2% in leave-on products.
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✅ Premium Quality Standards
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Purity (Assay) | ≥99.5% |
| Heavy Metals | ≤10 ppm (Pb ≤2 ppm) |
| Microbials | Complies with ISO 11930 |
| Shelf Life | 2 years (room temp, sealed) |
💡 Why Choose DropBrigt® HEPES?
Beyond buffering, this "smart" active:
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Rescues UV-stressed skin via melanin suppression.
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Boosts actives’ efficacy in serums, toners, and creams.
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Works synergistically with brightening powerhouses (vitamin C, tranexamic acid).
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Simplifies formulating with water solubility and process flexibility.
"HEPES isn’t just a pH adjuster—it’s a force multiplier for radiant skin results."
Elevate brightening formulations with DropBrigt® HEPES—where science meets synergy.
- If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.